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Conditions caused by insufficiency of progesterone Premenstrual stress syndrome. Mastopathy Premenapause Deficiency of progesterone in premenapause. Substitute therapy of menapause(in combination with estrogen medicationSubstitute hormonotherapy with the nonfunctioning ovaries in the case of the complete absence of progesterone (with the blood donation of egg cells) The maintenance of lutein phase during the preparation for the extracorporeal fertilization The maintenance of lutein phase in the spontaneous or induced menstrual cycle Sterility as a result of the lutein phase insufficiency; The prophylaxis of miscarriage as a result of progestin insufficiency; The threat of pregnancy isruption Endocrine sterility